Fig 6. Altering the inoculation route does not impact the expansion of antigen-experienced CD8⁺ T cells in female mice.

Male and female Ifnar^-/- mice were ip inoculated with 1x10⁴ PFU of CVB3. The spleen was harvested at 5dpi, and splenocytes were analyzed by flow cytometry. (A) Representative flow cytometry plots of CD8α^loCD11a^hi expression on CD8⁺ T cells from uninfected and infected male and female Ifnar^-/- mice following ip inoculation with CVB3. The frequency (B) and number (C) of CD8α^loCD11a^hi CD8⁺ T cells in uninfected and infected male and female Ifnar^-/- mice 5dpi. Data points in the scatter plots represent individual mice, with lines representing the mean from three experiments. *p<0.05, **p<0.01, ****p<0.0001, One-way ANOVA.