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. 2023 Sep 15;133(18):e168597. doi: 10.1172/JCI168597

Figure 4. Heatmap for z scores of interactions between CHIP mutations and predicted expression scores of inflammatory genes on CVD event incidence.

Figure 4

Only predicted expression scores significantly associated with CVD event incidence among participants with CHIP mutations were examined for their interactions in this step. Inflammatory genes were identified through canonical pathways and protein-protein interactions based on STRING. Predicted expression scores of examined genes were calculated by applying either the P+T or PRS-CS method to the summary statistics of the eQTL for those genes from the eQTLGen Consortium. CVD event outcome was defined as a composite of myocardial infarction, CAD or revascularization, stroke, or death. Black indicates a negative z score, and red indicates a positive z score. **Statistical significance at an FDR = 0.05 level; *statistical significance at an FDR = 0.1 level. The darker the color, the stronger the effects.