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. 2023 Sep 15;133(18):e162515. doi: 10.1172/JCI162515

Figure 7. Liver clock and gut microbes uniquely impact functional pathway enrichment of oscillating hepatic transcripts.

Figure 7

Diurnal transcriptome analysis of liver samples collected every 4 hours over 24 hours from SPF and GF WT and LKO male mice (n = 3/time point/group) maintained in 12:12 LD (ZT2, -6, -10, -14, -18, and -22). Reactome and KEGG pathways significantly enriched by oscillating transcripts within each group. A subset of pathways enriched in SPF WT oscillating genes (q < 0.05). A lack of bar indicates lack of significance for that group/pathway (q > 0.05). Pathways marked with red star are addressed in the text.