Table 1.

Included studies and participants by study type

	Offspring of affected parents		Control offspring		All offspring
Study type	n	N	n	N	N
Prospective family high‐risk	81	21,477	62	11,389	32,866
Cross‐sectional family high‐risk	112	69,918	77	9,008	78,926
Registry	18	3,080,720	18	20,408,178	23,488,898
Total	211	3,172,115	157	20,428,575	23,600,690