Table 2.

Multivariable-Adjusted Odds Ratios for Osteoporosis According to gSOS PRS Quintile

	Analysis, OR (95% CI) a; P Value
	Primary b	Sensitivity: Control c	Sensitivity: Case d
Normal BMD e	Controls (n = 289)	Controls (n = 623)	Controls (n = 289)
Osteopenia f	Excluded (n = 334)		Cases (n = 483)
Osteoporosis g	Cases (n = 149)	Cases (n = 149)
gSOS PRS quintile vs first
Second	2.53 (1.11–5.75); 0.027	1.63 (.81–3.26); .171	1.26 (.78–2.04); .349
Third	2.88 (1.27–6.55); .011	2.41 (1.23–4.73); .010	1.57 (.97–2.55); .066
Fourth	2.70 (1.20–6.03); .016	2.05 (1.05–3.99); .035	1.36 (.83–2.22); .217
Fifth	4.13 (1.86–9.18); < .001	2.34 (1.20–4.57); .013	2.30 (1.37–3.88); .002

Abbreviations: BMD, bone mineral density; gSOS, genetically predicted heel quantitative ultrasound speed of sound; OR, odds ratio; PRS, polygenic risk score.

All odds ratios are adjusted for traditional and HIV-related risk factors, including antiretrovirals.

Primary analysis: cases are defined as any T-score ≤ −2.5 or Z-score ≤ −2 in premenopausal women or men aged <50 years and with controls defined as all T-scores > −1.0.

Sensitivity analysis with controls defined as all T-scores > −2.5.

Sensitivity analysis with cases defined as any T-score ≤ −1.0 or Z-score ≤ −2 in premenopausal women or men aged <50 years.

T-score > −1.0.

T-score ≤ −1.0 and > −2.5.

T-score ≤ −2.5 or Z-score ≤ −2 in premenopausal women or men aged <50 years.