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. 2023 Aug 31;29(9):2325–2333. doi: 10.1038/s41591-023-02517-y

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© Moderna, Inc. 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Prebooster and day 29 nAb titers (log₁₀) against Omicron BA.4/BA.5, BQ.1.1, XBB.1 and XBB.1.5 variants in randomly selected subsets of participants in the mRNA-1273.222 booster group with (n = 20) and without (n = 40) prior SARS-CoV-2 infection. Prebooster and day 29 geometric mean titers and geometric mean fold-rises from baseline (X) are displayed above the corresponding data points. Antibody values reported as below the LLOQ (18.5 (1.3 in log₁₀ scale) for ancestral SARS-CoV-2 (D614G) and 36.7 (1.6 in log₁₀ scale) for Omicron BA.4/BA.5) were replaced by 0.5 × LLOQ. Values greater than the ULOQ (45,118 (4.7 in log₁₀ scale) for ancestral SARS-CoV-2 (D614G); 13,705 (4.1 in log₁₀ scale) for Omicron BA.4/BA.5) were replaced by the ULOQ if actual values were not available. The limit of detection (LOD) of the pseudovirus nAb assay for BQ.1.1, XBB.1 and XBB.1.5 was 10; antibody values reported as below the LOD are replaced by 0.5 × LOD. Boxes and horizontal bars denote IQR and median endpoint titers; whisker endpoints are the maximum and minimum values below or above the median ±1.5 times the IQR.