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. 2023 Aug 31;29(9):2325–2333. doi: 10.1038/s41591-023-02517-y

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© Moderna, Inc. 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 1 — Distribution of neutralizing antibody titers (ID50 log₁₀) in the pseudovirus assay against Omicron BA.4/BA.5 (Panel A) and ancestral SARS-CoV-2 (D614G) (Panel B) are shown for serum samples collected before the second booster dose of 50-µg of mRNA-1273.222 or 50-µg of mRNA-1273 (prebooster), and at 28 days after the second booster dose (day 29) in those with and without prior SARS-CoV-2 infection. The circles are values from individual serum samples. Pseudovirus neutralizing antibody assay lower limits of quantification (LLOQ) are 18.5 (1.3 log₁₀) for ancestral SARS-CoV-2 [D614G] and 36.7 (1.6 log₁₀) for Omicron BA.4/BA.5; upper limits of quantification (ULOQ) are 45,118 (4.7 log₁₀) for ancestral SARS-CoV-2 [D614G] and 13,705 (4.1 log₁₀) for Omicron BA.4/BA.5. Boxes and horizontal bars denote interquartile (IQR) ranges and median endpoint titers; whisker endpoints are the maximum and minimum values below or above the median ±1.5 times the IQR. Refer to Table 2 for the observed geometric mean titers and geometric mean fold-rises, and the estimated neutralizing antibody geometric mean titers and geometric mean ratios (ANCOVA model-based) following the second booster doses of 50-µg mRNA-1273 or 50-µg of mRNA-1273.214.