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. 2023 Aug 31;29(9):2325–2333. doi: 10.1038/s41591-023-02517-y

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© Moderna, Inc. 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — Neutralizing antibody titers against Omicron BA.4/BA.5 and ancestral SARS-CoV-2 (a) and geometric fold-rises from baseline levels (b) were assessed in participants without previous infection grouped by quartiles of dosing intervals between the first booster dose of mRNA-1273 and second booster doses of mRNA-1273 and mRNA-1273.222 post boost within each booster vaccine group at day 29. 95% CIs were calculated based on the t-distribution of the log-transformed values for GM value, then back-transformed to the original scale for presentation. Quartiles 1, 2, 3 and 4 represent quartiles indicated s in panel a for mRNA-1273 and mRNA-1273.222.