Extended Data Fig. 4. Reductions in serum ANGPTL3, TG, LDL-C, VLDL-C, HDL-C, non-HDL-C, and ApoB concentrations in healthy participants with multiple ascending doses of ARO-ANG3.

Median percent change (Q1, Q3) from baseline in triglycerides (B). Mean percent change (±SD) from baseline in ANGPTL3 (A), VLDL-C (C), non-HDL-C (D), LDL-C (E), HDL-C (F), and ApoB (G) in healthy participants receiving a subcutaneous dose of ARO-ANG3 (n = 4 per cohort of 100 mg [red], 200 mg [green] or 300 mg [purple]) on Days 1 and 29). Abbreviations: ApoB = Apolipoprotein B; HDL-C = high density lipoprotein cholesterol; Q1 = quartile 1; Q3 = quartile 3; LDL-C = low density lipoprotein cholesterol; SD = standard deviation; VLDL = very low density cholesterol.