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. 2023 Jun 8;7(9):1097–1112. doi: 10.1038/s41551-023-01050-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — (a) Organ autoradiography 24 h after ⁸⁹Zr-IL4-aNPs injection in mice. (b) Gamma count in vital organs 24 h after ⁸⁹Zr-IL4-aNPs injection in mice (n = 5). (c) Uptake ratios by target organs over clearance organs in mice 2-way ANOVA with Turkey post-hoc analysis. (d) Dynamic PET/MRI scans of non-human primates at 1, 30, and 60 minutes after ⁸⁹Zr-IL4-aNPs injection. (e) Organ-specific SUVmean in non-human primates over 1 hour following ⁸⁹Zr-IL4-aNPs administration. (f) Gating strategy for bone marrow (top) and spleen (bottom) in experiments to measure cell type-specificity of DiO-labelled discoidal IL4-aNPs. Data are presented as mean ± SD where appropriate.