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. 2023 Jun 8;7(9):1097–1112. doi: 10.1038/s41551-023-01050-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — (a) TNF/IL6 production after re-stimulation of cells that were trained with IL4 whilst blocking key IL4 signaling routes (b) Fold increase of TNF/IL6 after re-stimulation of cells that were trained with IL4 whilst blocking key IL4 signaling routes. (c) Heatmap of the transcriptome of monocytes directly after isolation, and after stimulation with RPMI, IL4, LPS, or LPS+IL4. (d) Transcription factor motif enrichment analysis of acute IL4 effects on LPS-stimulated monocytes. (e) Pathway enrichment analyses of IL4’s effect on acute LPS stimulation. (f) ChIP-qPCR analysis of TNF in IL4-trained cells. Data are presented as mean ± SD.