Fig. 1. Illustrated overview of dentatothalamocortical pathway depicting a single deep brain stimulation lead implanted in the left dentate nucleus (brown).

The crossed dentatothalamic projections (blue in upper-left illustration) terminate across multiple contralateral thalamic (green) nuclei that, in turn, project (orange), to broad regions of cerebral cortex. The dentatothalamocortical pathway represents the ascending component of a robust, reciprocal loop interconnecting the cerebral cortex with the contralateral cerebellar hemisphere. DN is shown in brown. RN, red nucleus; PN, pontine nuclei.