Fig. 7. Amph-FITC CAR T cell therapy is efficacious when translated to human FITC CAR T cells in human solid tumour xenografts.
a, Expression of humanized FITC CARs. b, Schematic and timeline of therapy in NSG mice. Created with Biorender.com. c,d, Bioluminescence imaging (c) and quantification (d) of FLuc+ CAR T cell trafficking in NSG mice (n = 5 animals per group). e, MSTO-211H tumour growth of NSG mice following treatment with E2-hBBz CAR T cells (n = 10 animals per group). All replicates were biological replicates. P values were determined by two-way ANOVA. Error bars represent standard error of the mean. **P < 0.01; ***P < 0.001. NS, not significant.