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. 2023 Aug 31;29(9):2295–2306. doi: 10.1038/s41591-023-02491-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — (a) Pre-therapy (post CAR T and pre TCE, sample number P2085) versus post-relapse (post TCE, P3101) circos plot based on WGS. Outer track runs clockwise from chromosome 1 to Y. Inner track shows CNVs (gains in light blue, losses in salmon). Lines inside the circle represent SVs (deletions in red, duplications in green, inversions in blue, interchromosomal translocations in black, and chromoplexy in grey). Clonal phylogeny inferred from WGS data. (b) Copy number and structural variations at TNFRSF17 locus. Translocations in black, deletions in red, duplications in green, inversions in blue. (c) IGV screenshot of pre- versus post-relapse CD138+ cells, illustrating newly detected p.Pro34del and p.Ser30del at relapse.