Extended Data Fig. 3. Pre-therapy circos plot of patient MM-03 based on WGS.

Outer track runs clockwise from chromosome 1 to Y. Inner track shows CNVs (gains in light blue, losses in salmon). Lines inside the circle represent structural variations (SV) with deletions in red, duplications in green, inversions in blue, interchromosomal translocations in black, and chromoplexy in grey.