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. 2023 Sep 15;14:174. doi: 10.1007/s12672-023-00784-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Epithelial cells in brain metastases are more malignant. A Copy number variation in Epithelial cells, endothelial cells, and fibroblasts were used as a reference, red represents overexpression of genes, and blue represents low expression. B Violin plot indicating the CNV scores of Epithelial cells from lung adenocarcinoma and brain metastases. C Heatmap showing the top 50 differential expressed genes between the two groups. D Differences in pathway activities by GSVA between lung adenocarcinoma and brain metastases epithelial cells