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. 2023 Sep 15;13:15287. doi: 10.1038/s41598-023-42495-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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TMB and clonal TMB are significantly associated with the response to ICI. (a) Relationship between TMB and response to ICI treatment. TMB values were significantly higher in responders than in non-responders (Wilcoxon test, p value = 0.046). (b) Relationship between stop mutations and response to ICI treatment. Nonsense mutations were significantly higher in responders than in non-responder (Wilcoxon test, p value = 0.037). (c) Relationship between frameshift mutations and response to ICI treatment. Frameshift mutations showed a trend of being more abundant in responders than non-responders but the difference was not statistically significant (p = 0.3). (d) Number of mutations per patient divided in clonal and subclonal. The proportion of clonal mutations is significantly higher in responders (Fisher’s exact test p value = 0.007). (e) Relationship between clonal TMB and response to ICI treatment. Clonal TMB values were significantly higher in responders than in non-responders (Wilcoxon text, p value = 0.017). (f) Relationship between subclonal TMB and response to ICI treatment. Responders tend to have higher values but the difference between responders and non-responders is not statistically significant. NR no responders, R responders, triangle shape represents complete responders among the group of responders.