Figure 3.

Effects of Chronic Liraglutide Treatment on AF and AERP in db/db Mice

(A) Representative surface ECG (top) and atrial intracardiac EGM (bottom) showing induction of AF and conversion to SR in a vehicle-injected db/db mouse. (B) Inducibility of AF in wild-type mice, db/db mice given daily vehicle injections (db/db_veh), and db/db mice given daily injections of liraglutide for 4 weeks (db/db_lira). Numbers in parentheses indicate the number of mice induced into AF. Data analyzed by Fisher exact test. (C) Duration of AF in wild-type, db/db_veh, and db/db_lira mice that were induced into AF. (D) AERP in wild-type (n = 13), db/db_veh (n = 16), and db/db_lira (n = 11) mice. Data analyzed by one-way analysis of variance with Holm-Sidak post hoc test. ∗∗P < 0.01, ∗∗∗P < 0.001. Abbreviations as in Figure 1.