Figure 5.

Effects of Chronic GLP-1 on Atrial Conduction and Atrial Optical AP Morphology in db/db Hearts

(A) Representative activation maps in isolated atrial preparations from wild-type, db/db_saline, and db/db_GLP-1 mice paced at 8 Hz. Right atrial appendage is on the left side of the image. Color scale indicates total conduction time across the preparation. Bars = 2 mm. (B, C) Summary of right atrial (B) and left atrial (C) conduction velocity (CV) in wild-type, db/db_saline, and db/db_GLP-1 mice. (D) Representative right atrial and left atrial optical action potentials (APs) in isolated atrial preparations from wild-type, db/db_saline, and db/db_GLP-1 mice. (E) Representative action potential duration maps at 50% repolarization time (APD₅₀) in atrial preparations from wild-type, db/db_saline, and db/db_GLP-1 mice. Bars = 2 mm. (F, G) Summary of right (F) and left (G) atrial APD₅₀ in atrial preparations from wild-type, db/db_saline, and db/db_GLP-1 mice. (H, I) Summary of right (H) and left (I) atrial APD₇₀ in atrial preparations from wild-type, db/db_saline, and db/db_GLP-1 mice. Summary data analyzed by one-way analysis of variance with Holm-Sidak post hoc test; n = 5-6 atrial preparations per group. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001. Abbreviations as in Figure 1.