Figure 6.

Effects of Chronic GLP-1 on AP Morphology in Isolated Left Atrial Myocytes in db/db Mice

(A) Representative stimulated APs in left atrial myocytes isolated from wild-type, db/db_saline, and db/db_GLP-1 mice. (B to I) Summary data for cell capacitance (B), resting membrane potential (RMP) (C), AP upstroke velocity (V_max) (D), overshoot (E), APD₂₀(F), APD₅₀(G), APD₇₀(H), and APD₉₀(I) in isolated left atrial myocytes from wild-type, db/db_saline, and db/db_GLP-1 mice. Data analyzed by one-way analysis of variance with Holm-Sidak post hoc test; n = 8 myocytes from 2 mice for wild type, 13 myocytes from 5 mice for db/db_saline, and 17 cells from 9 mice for db/db_GLP-1. ∗P < 0.05, ∗∗∗P < 0.001. Abbreviations as in Figures 1 and 5.