Figure 7.

Effects of Chronic GLP-1 on K⁺ Currents in Isolated Left Atrial Myocytes in db/db Mice

(A) Representative K⁺ current (I_K) recordings for total I_K(left) and I_K after an inactivating prepulse to −40 mV (right) in left atrial myocytes isolated from wild-type, db/db_saline, and db/db_GLP-1 mice. Voltage clamp protocols shown below recordings. (B) I_K current-voltage (IV) curves measured at the peak of the total I_K recordings. (C) I_K IV curves (same data as B) showing repolarizing I_K at membrane potentials positive to 0 mV. (D) I_K IV curves measured at the peak of the I_K recordings after an inactivating prepulse. (E) I_K IV curves after an inactivating prepulse (same data as D) showing I_K at membrane potentials positive to 0 mV. ∗P < 0.05 vs wild type, ⁺P < 0.05 vs db/db_saline by mixed-effects analysis of variance with Holm-Sidak post hoc test; n = 7 myocytes from 2 mice for wild type, 11 myocytes from 3 mice for db/db_saline, and 15 myocytes from 5 mice for db/db_GLP-1. Statistical symbols shown only on C and E for clarity. Abbreviations as in Figure 1.