Table 2.

Incident diagnosis of cardiovascular outcomes

	Number of new-onset occurrence per women			Number of new-onset occurrence per 1,000 women-years of follow-up			Unadjusted p value		Adjusted p value*
Outcomes	Group 1, Low genetic risk for HDP (n = 41,177)	Group 2, Medium genetic risk for HDP (n = 82,275)	Group 3, High genetic risk for HDP (n = 41,123)	Group 1, Low genetic risk for HDP (n = 41,177)	Group 2, Medium genetic risk for HDP (n = 82,275)	Group 3, High genetic risk for HDP (n = 41,123)	Group 1 vs. Group 2	Group 1 vs Group 3	Group 1 vs. Group 2	Group 1 vs Group 3
Total ASCVD	2,093 (5.1%)	4,468 (5.4%)	2,381 (5.8%)	4.26	4.55	4.86	0.012	<0.001	0.352	0.003
Coronary artery disease	1,619 (3.9%)	3,437 (4.2%)	1,880 (4.6%)	3.35	3.56	3.91	0.035	<0.001	0.347	0.013
Myocardial infarction	365 (0.9%)	756 (0.9%)	482 (1.2%)	0.74	0.77	0.98	0.572	<0.001	0.999	0.002
Ischemic stroke	494 (1.2%)	1,054 (1.3%)	516 (1.3%)	1.01	1.08	1.06	0.218	0.445	0.402	0.868
Peripheral artery disease	278 (0.7%)	594 (0.7%)	362 (0.9%)	0.57	0.61	0.74	0.351	<0.001	0.867	0.033

Data are presented as proportion (%).

Abbreviations: ASCVD, atherosclerotic cardiovascular disease

^*adjusted for hypertensive disease during pregnancy, age, BMI, smoking, prevalent disease (hypertension, diabetes, or hypercholesterolemia), PCs (principal component) and genotype arrays by cox proportional hazards regression analysis