Table 5.
T cell receptor beta variable (TRBV) genes with significantly different allele frequency variants between cases and controls
| TCR GENES |
TRBV5_5 |
TRBV6_5 |
TRBV7_3 |
TRBV7_6 |
TRBV7_7 |
TRBV7_8 |
TRBV10_1 |
TRBV30 |
|---|---|---|---|---|---|---|---|---|
| #Variants of Concern in Gene |
1 |
3 |
4 |
3 |
3 |
3 |
7 |
1 |
| PATIENT ID | #HI Alleles | #HI Alleles | #HI Alleles | #HI Alleles | #HI Alleles | #HI Alleles | #HI Alleles | #HI Alleles |
| AR5440 | 1 | 3 | 4 | 3 | 3 | 2 | 7 | 2 |
| AR5443 | 1 | 3 | 4 | 3 | 3 | 3 | 8 | 0 |
| AR5444 | 1 | 3 | 4 | 3 | 3 | 3 | 6 | 0 |
| AR5445 | 1 | 3 | 4 | 3 | 3 | 0 | 6 | 1 |
| AR5446 | 1 | 3 | 4 | 3 | 3 | 3 | 8 | 1 |
| AR5447 | 1 | 3 | 4 | 3 | 3 | 3 | 7 | 0 |
| AR5448 | 1 | 3 | 4 | 3 | 3 | 2 | 7 | 0 |
| AR5449 | 1 | 3 | 4 | 3 | 3 | 2 | 6 | 1 |
| AR5450 | 1 | 3 | 4 | 3 | 3 | 3 | 7 | 2 |
| AR5451 | 1 | 3 | 4 | 3 | 3 | 0 | 7 | 0 |
| AR5452 | 1 | 3 | 4 | 3 | 3 | 0 | 6 | 2 |
| AR5454 | 1 | 3 | 4 | 3 | 3 | 3 | 7 | 0 |
| AR5455 | 1 | 3 | 4 | 3 | 3 | 0 | 7 | 0 |
| AR5457 | 1 | 3 | 4 | 3 | 3 | 2 | 7 | 0 |
| AR5458 | 1 | 3 | 4 | 3 | 3 | 3 | 6 | 2 |
| AR5459 | 1 | 3 | 4 | 3 | 3 | 3 | 8 | 0 |
| AR5460 | 1 | 3 | 4 | 3 | 3 | 2 | 7 | 0 |
| AR5461 | 1 | 3 | 4 | 3 | 3 | 0 | 7 | 0 |
| AR5462 | 1 | 3 | 4 | 3 | 3 | 3 | 6 | 1 |
| AR5463 | 1 | 3 | 4 | 3 | 3 | 3 | 7 | 0 |
| AR5464 | 1 | 3 | 4 | 3 | 3 | 0 | 6 | 1 |
| AR5465 | 1 | 3 | 2 | 3 | 3 | 0 | 7 | 2 |
| AR5466 | 1 | 3 | 4 | 3 | 3 | 3 | 7 | 1 |
| AR5467 | 1 | 3 | 4 | 3 | 3 | 2 | 7 | 0 |
| AR5468 | 1 | 3 | 4 | 3 | 3 | 2 | 7 | 2 |
| AR5469 | 1 | 3 | 4 | 3 | 3 | 3 | 8 | 0 |
| AR5470 | 1 | 3 | 4 | 3 | 3 | 3 | 7 | 1 |
| AR5472 | 1 | 3 | 4 | 3 | 3 | 3 | 6 | 0 |
| AR5473 | 1 | 3 | 4 | 3 | 3 | 3 | 7 | 1 |
| AR5474 | 1 | 3 | 4 | 3 | 3 | 0 | 8 | 0 |
| AR5475 | 1 | 3 | 4 | 3 | 3 | 0 | 7 | 1 |
| AR5476 | 1 | 3 | 4 | 3 | 3 | 0 | 8 | 0 |
| AR5477 | 1 | 3 | 4 | 3 | 3 | 3 | 8 | 0 |
| AR5478 | 1 | 3 | 4 | 3 | 3 | 0 | 7 | 1 |
| AR5481 | 1 | 3 | 4 | 3 | 3 | 0 | 8 | 1 |
| AR5484 | 1 | 3 | 4 | 3 | 3 | 0 | 7 | 0 |
| AR5485 | 1 | 3 | 4 | 3 | 3 | 0 | 6 | 0 |
| AR5486 | 1 | 3 | 4 | 3 | 3 | 3 | 6 | 0 |
| AR5487 | 1 | 3 | 4 | 3 | 3 | 0 | 7 | 1 |
| AR5488 | 1 | 3 | 4 | 3 | 3 | 3 | 7 | 2 |
| AR5490 | 1 | 3 | 4 | 3 | 3 | 0 | 6 | 0 |
| AR5492 | 1 | 3 | 4 | 3 | 3 | 3 | 7 | 0 |
| AR5493 | 1 | 3 | 4 | 3 | 3 | 3 | 7 | 2 |
| AR5495 | 1 | 3 | 4 | 3 | 3 | 2 | 6 | 1 |
| AR5496 | 1 | 3 | 4 | 3 | 3 | 3 | 7 | 1 |
| AR5497 | 1 | 3 | 4 | 3 | 3 | 3 | 6 | 0 |
| AR5499 | 1 | 3 | 4 | 3 | 3 | 2 | 7 | 0 |
| AR5500 | 1 | 3 | 4 | 3 | 3 | 2 | 8 | 1 |
| AR5501 | 1 | 3 | 4 | 3 | 3 | 0 | 6 | 0 |
| AR5502 | 1 | 3 | 4 | 3 | 3 | 3 | 7 | 2 |
| AR5503 | 1 | 3 | 4 | 3 | 3 | 0 | 7 | 0 |
| AR5506 | 1 | 3 | 4 | 3 | 3 | 3 | 7 | 1 |
| AR5507 | 1 | 3 | 4 | 3 | 3 | 0 | 7 | 1 |
| AR5508 | 1 | 3 | 4 | 3 | 3 | 3 | 6 | 1 |
| AR5510 | 1 | 3 | 4 | 3 | 3 | 3 | 7 | 1 |
| AR5511 | 1 | 3 | 4 | 3 | 3 | 3 | 8 | 0 |
| AR5512 | 1 | 3 | 4 | 3 | 3 | 0 | 8 | 0 |
| AR5513 | 1 | 3 | 4 | 3 | 3 | 0 | 8 | 1 |
| AR5514 | 1 | 3 | 4 | 3 | 3 | 3 | 8 | 1 |
| AR5516 | 1 | 3 | 4 | 3 | 3 | 2 | 7 | 0 |
| AR5517 | 1 | 3 | 4 | 3 | 3 | 3 | 6 | 2 |
| AR5518 | 1 | 3 | 4 | 3 | 3 | 2 | 7 | 1 |
| AR5520 | 1 | 3 | 4 | 3 | 3 | 3 | 7 | 1 |
| AR5521 | 1 | 3 | 4 | 3 | 3 | 3 | 6 | 1 |
| AR5522 | 1 | 3 | 4 | 3 | 3 | 2 | 7 | 1 |
| AR5524 | 1 | 3 | 4 | 3 | 3 | 3 | 7 | 2 |
| AR5526 | 1 | 3 | 4 | 3 | 3 | 2 | 7 | 1 |
| AR5527 | 1 | 3 | 4 | 3 | 3 | 2 | 8 | 0 |
| AR5530 | 1 | 3 | 4 | 3 | 3 | 2 | 7 | 1 |
| AR5533 | 1 | 3 | 4 | 3 | 3 | 2 | 6 | 0 |
| AR5535 | 1 | 3 | 4 | 3 | 3 | 3 | 8 | 1 |
| AR5536 | 1 | 3 | 4 | 3 | 3 | 0 | 8 | 2 |
| AR5538 | 1 | 3 | 4 | 3 | 3 | 3 | 7 | 0 |
| AR5539 | 1 | 3 | 4 | 3 | 3 | 3 | 6 | 0 |
For each gene we highlight the total number of variants of concern as well as the number of high impact alleles each patient has in each gene for those variants. In red we highlight those genes containing more than 3 high impact alleles, indicating a potential loss of function in both alleles for the gene.