Table 2. SwissADME values of selected thio azo compounds (1-6).

Compound	log Kp (cm/s)	GI absorption	BBB permeant	Pgp substrate	CYP1A2 inhibitor	CYP2C19 inhibitor	CYP2C9 inhibitor	CYP2D6 inhibitor	CYP3A4 inhibitor
1	-4.98	High	No	No	Yes	Yes	Yes	No	Yes
2	-5.05	High	No	No	Yes	Yes	Yes	No	No
3	-6.28	High	No	Yes	Yes	Yes	Yes	Yes	Yes
4	-6.4	High	No	Yes	Yes	Yes	Yes	Yes	Yes
5	-4.94	Low	No	No	No	Yes	Yes	No	Yes
6	-3.59	Low	No	No	No	No	No	No	No
Doxorubicin	-8.71	Low	No	Yes	No	No	No	No	No
Paclitaxel	-8.91	Low	No	Yes	No	No	No	No	No
Tamoxifen	-3.5	Low	No	Yes	No	Yes	No	Yes	No