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. 2023 Jan 1;19(1):99–104. doi: 10.6026/97320630019099

Table 3. Lipinski and Veber rules of selected thioazo compounds (1-6).

Compound MW iLogP HBD (nOHNH) HBA (nON) nrotb MR TPSA Lipinski #violations Bio availability score
Lipinski* ≤500 ≤5 ≤5 ≤10 ≤10 - -
Veber** - - - - - - ≤ 140
1 328.82 2.65 1 3 4 92.64 78.41 0 0.55
2 314.79 2.26 1 3 4 87.83 78.41 0 0.55
3 404.48 3.47 1 4 6 116.59 93.2 0 0.55
4 418.51 3.84 0 4 6 121.49 82.34 0 0.55
5 421.47 3.4 1 5 6 120.97 122.33 0 0.55
6 720.5 6.24 2 4 9 181.57 124.78 2 0.17
Doxorubicin 543.52 2.16 6 12 5 132.66 206.07 3 0.17
Paclitaxel 853.91 4.51 4 14 15 218.96 221.29 2 0.17
Tamoxifen 371.51 4.64 0 2 8 119.72 12.47 1 0.55