Table 2. ADME values of selected aza compounds (1-6).

Compound	log Kp (cm/s)	GI absorption	BBB permeant	Pgp substrate	CYP1A2 inhibitor	CYP2C19 inhibitor	CYP2C9 inhibitor	CYP2D6 inhibitor	CYP3A4 inhibitor
1	-5.42	Low	No	Yes	No	Yes	No	No	No
2	-5.64	Low	No	No	No	Yes	Yes	No	No
3	-5.17	Low	No	No	No	Yes	Yes	Yes	No
4	-5.43	Low	No	Yes	No	Yes	Yes	No	No
5	-6.26	Low	No	No	No	No	Yes	No	No
6	-5.01	Low	No	No	No	Yes	Yes	Yes	No
Amoxicillin	-9.94	Low	No	No	No	No	No	No	No
Moxifloxacin	-8.32	High	No	Yes	No	No	No	Yes	No
Sulfanilamide	-7.79	High	No	No	No	No	No	No	No
Sulfamethoxazole	-7.21	High	No	No	No	No	No	No	No