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. 2023 Jan 31;19(1):53–56. doi: 10.6026/97320630019053

Table 3. Lipinski and Veber rules of selected aza compounds (1-6).

Compound MW iLogP HBD (nOHNH) HBA (nON) nrotb MR TPSA Lipinski #violations Bio availability score
Lipinski* ≤500 ≤5 ≤5 ≤10 ≤10 - -
Veber** - - - - - - ≤ 140
1 430.52 3 3 6 5 124.02 133.27 0 0.55
2 446.52 2.95 3 7 6 124.65 125.52 0 0.55
3 474.57 3.6 3 7 8 134.26 125.52 0 0.55
4 488.6 3.35 2 7 8 139.16 116.73 0 0.55
5 448.49 2.82 4 8 5 121.77 159.74 0 0.55
6 488.6 3.35 3 7 9 139.07 125.52 0 0.55
Amoxicillin 365.4 1.46 4 6 5 94.59 158.26 0 0.55
Moxifloxacin 401.43 2.78 2 6 4 114.05 83.8 0 0.55
Sulfanilamide 172.2 0.61 2 3 1 41.84 94.56 0 0.55
Sulfamethoxazole 253.28 1.03 2 4 3 62.99 106.6 0 0.55