Table 1. Molecular docking interaction of indole based diaza-sulphonamide compounds (1-9) against JAK-3 protein of Homo sapiens (PDB ID: 1YVJ).

Ligands	Docking scores/Affinity (kcal/mol)	H-bond	Amino Acid Residual interactions
			Hydrophobic/Pi-Cation	Van dar Waals
1	-9.3	Arg-911, Leu-828		Gly-829, Asp-967, Gln-988, Lys-830, Cys-909, Glu-903, Leu-905, Tyr-904
2	-9.7	Leu-828, Arg-911, Gln-988	Leu-956, Ala-853, Val-836, Arg-953	Cys-909, Lys-830, Gly-829, Asn-954, Asp-967, Ala-966, Glu-903, Tyr-904, Leu-905,
3	-9	Gln-988, Arg-911,	Val-836, Arg-953, Leu-828, Ala-853, Leu-905, Tyr-904, Leu-956, Cys-909	Glu-903, Lys-830, Asn-954, Asp-967, Gly-829
4	-9.8	Cys-909	Lys-855, Val-836, Gly-829, Leu-828, Ala-853, Leu-956, Asn-954	Leu-905, Asp-912, Asp-967, Phe-833, Gly-834, Ser-835, Gly-831, Lys-830
5	-8.8	Arg-911	Arg-953, Gln-988, Val-836, Ala-853, Val-884, Met-902, Leu-956, Leu-828	Asn-954, Lys-830, Gly-829, Leu-905, Glu-903,
6	-9.7	Arg-953, Cys-909	Lys-855, Asp-967, Val-836, Leu-828, Leu-956, Met-902, Ala-853, Gly-829, Asn-954	Gln-988, Phe-833, Gly-908, Tyr-904, Leu-905, Asp-912
7	-9.6	Arg-911, Gln-988	Leu-828, Leu-956, Ala-853, Val-836, Arg-953	Cys-909, Lys-830, Gly-829, Asn-954, Asp-967, Glu-903, Tyr-904, Leu-905
8	-9.6	Cys-909	Val-836, Leu-828, Leu-956, Met-902, Ala-853, Gly-829, Asp-967, Lys-855	Gln-988, Gly-908, Leu-905, Asn-954, Phe-833
9	-9.3	Arg-911	Val-836, Cys-909, Ala-853, Leu-905, Tyr-904, Leu-828, Leu-956, Arg-953	Cly-829, Gln-988, Lys-830, Glu-903
Doxorubicin	-9	Gln-988, Asp-967,	Leu-828, Val-836, Leu-956	Leu-905, Tyr-904, Val-884, Ala-966, Phe-968, Asn-954, Arg-953, Asp-912, Cys-909
Paclitaxel	-8	Cys-909, Arg-911, Arg-916,	Leu-956, Leu-828, Ala-853, Arg-953, Asp-912, Gly-908	Asn-954, Leu-905, Pro-906, Tyr-904
Tamoxifen	-7.5		Cys-909, Leu-828, Leu-956, Gly-829, Val-836	Asn-954, Gly-908, Leu-905, Asp-967, Lys-855, Ser-835, Gly-831, Gln-988