Table 2. SwissADME values of selected indole based diaza-sulphonamide compounds (1-9).

Compound	log Kp (cm/s)	GI absorption	BBB permeant	Pgp substrate	CYP1A2 inhibitor	CYP2C19 inhibitor	CYP2C9 inhibitor	CYP2D6 inhibitor	CYP3A4 inhibitor
1	-6.54	High	No	No	Yes	Yes	Yes	Yes	Yes
2	-6.36	High	No	No	Yes	Yes	Yes	Yes	Yes
3	-6.36	High	No	No	Yes	Yes	Yes	Yes	Yes
4	-6.19	Low	No	No	Yes	Yes	Yes	Yes	Yes
5	-6.3	Low	No	No	Yes	Yes	Yes	Yes	Yes
6	-6.12	Low	No	No	Yes	Yes	Yes	Yes	Yes
7	-6.3	Low	No	No	Yes	Yes	Yes	Yes	Yes
8	-6.06	Low	No	No	Yes	Yes	Yes	Yes	Yes
9	-6.12	Low	No	No	Yes	Yes	Yes	Yes	Yes
Doxorubicin	-8.71	Low	No	Yes	No	No	No	No	No
Paclitaxel	-8.91	Low	No	Yes	No	No	No	No	No
Tamoxifen	-3.5	Low	No	Yes	No	Yes	No	Yes	No