Table 3. Lipinski and Veber rules of selected diazole-thiole compounds (1-6).

Compound	MW	iLogP	HBD (nOHNH)	HBA (nON)	nrotb	MR	TPSA	Lipinski #violations	Bio availability score
Lipinski*	≤500	≤5	≤5	≤10	≤10	-	-
Veber**	-	-	-	-	-	-	≤ 140
1	441.91	3.09	2	5	6	114.93	150.24	0	0.55
2	451.52	3.03	2	6	8	121.22	159.47	0	0.55
3	421.5	3.1	2	5	6	114.89	150.24	0	0.55
4	407.47	2.71	2	5	6	109.92	150.24	0	0.55
5	452.47	2	2	7	7	118.74	196.06	0	0.55
6	486.36	3.16	2	5	6	117.62	150.24	0	0.55
Azithromycin	748.98	4.76	5	14	7	200.78	180.08	2	0.17
Sulfanilamide	172.2	0.61	2	3	1	41.84	94.56	0	0.55
Sulfamethoxazole	253.28	1.03	2	4	3	62.99	106.6	0	0.55