Table 2.
Characteristics of the study population
| Characteristics | N = 160 |
|---|---|
| Median age (years) | 58 (18–86) |
| Male | 120 (75%) |
| Female | 40 (25%) |
| Charlson comorbidity index (mean) | 4 |
| PITT bacteremia score (mean) | 6 |
| SOFA score (mean) | 16 |
| Prior exposure to a carbapenem | 58 (36.25%) |
| Source of sepsis | |
| Line related | 38 (23.75%) |
| Unclear | 36 (22.5%) |
| Intra-abdominal | 36 (22.5%) |
| Pneumonia | 22 (13.75%) |
| Urinary | 20 (12.5%) |
| SSTI–Skin and soft tissue infection | 7 (4.37%) |
| Meningitis | 1 (0.62%) |
| Organisms (n = 164) | |
| Klebsiella pneumoniae | 77 (46.95%) |
| Escherichia coli | 39 (23.78%) |
| Enterobacter cloacae | 6 (3.65%) |
| Citrobacter koseri | 2 (1.22%) |
| Serratia marcescens | 2 (1.22%) |
| Morganella morganii | 1 (0.61%) |
| Acinetobacter baumannii | 16 (9.75%) |
| Pseudomonas aeruginosa | 7 (4.26%) |
| Pseudomonas stutzeri | 1 (0.61%) |
| Pseudomonas putida | 2 (1.22%) |
| Burkholderia pseudomallei | 2 (1.22%) |
| Burkholderia cepacia | 2 (1.22%) |
| Aeromonas hydrophila | 3 (1.65%) |
| Ralstonia mannitolilytica | 1 (0.61%) |
| Stenotrophomonas maltophilia | 2 (1.22%) |
| Elizabethkingia meningoseptica | 1 (0.61%) |
| Status on day 14 | |
| Alive | 109 (68.13%) |
| Dead | 44 (27.5%) |
| Not known | 7 (4.37%) |
| Status on day 30 | |
| Alive | 72 (45.00%) |
| Dead | 63 (39.37%) |
| Not known | 25 (15.62%) |
| No. of patients died | 67 (41.87%) |
| Median time to death from index bacteremia (days) | 9 |
| Median time to Carba-R (hours:min) | 30:34 |
| Median time to routine DST (hours:min) | 74:20 |