Table 6.

Decision taken by physician based on Carba-R^*

N = 144	Positive CR gene (n = 52)		Negative CR gene (n = 92)
Action and appropriateness	Appropriate (47)	Inappropriate (5)	Appropriate (78)	Inappropriate (14)
Escalation done (16)	14 (9.72%)	2 (1.38%) **	–	–
De-escalation done (41)	–	–	39 (27.08%)***	2 (1.38%)$
De-escalation not done (13)	–	–	7 (4.86%)	6 (4.16%)**
No action	33 (22.91%)	3 (2.08%)**	32 (22.22%)	6 (4.16%)$

^*16 patients were excluded from this analysis including 10 patients from CR gene –ve group, i.e., 3 isolates (DST known prior to Carba R), Burkholderia sp (n = 4), Stenotrophomonas (n = 2), Elizabethkingia (n = 1) and 6 from +ve CR gene group (carbapenem and colistin-resistant Klebsiella) were excluded;

^**patients received unnecessary CR over [2 + 3 + 6 = 11(7.63%)];

^***27.08% de-escalated from CR cover;

^$Indicates patients who did not get appropriate antibiotic cover before DST (8/144) – 5.55%