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. Author manuscript; available in PMC: 2023 Sep 16.
Published in final edited form as: Cell Rep. 2023 Aug 3;42(8):112924. doi: 10.1016/j.celrep.2023.112924

Figure 1. TCF-1 is critical for the development of non-LTi ILCs but not LTi cells.

Figure 1.

(A) BM cells were isolated from WT and Tcf7fl/flVavCre mice, and ILC2p, LTip, and PLZF+ ILC progenitor populations were analyzed by flow cytometry. Bar graphs show quantification in percentages and total cell numbers.

(B) ILC (Lin−CD127+) population in the siLP of the Tcf7fl/flVavCre mice were characterized by intracellular GATA3 and RORγt staining. The RORγt+ ILC3s were further analyzed based on their CCR6 and NKp46 expression. Bar graphs show quantification in percentages and total cell numbers. Bar graphs show quantification of total LTi cell numbers. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001; ns, not significant, Student’s t test. Data are representative of at least three independent experiments. See also Figure S1.