Fig. 4.

NPC administration increases inflammatory responses in the blood of hyperlipidemic mice but reduces inflammatory responses of normolipidemic mice. Total counts and activation states of leukocytes and leukocyte subsets in the blood of MCAO mice on normal diet or cholesterol-rich Western diet, which were intravenously treated with vehicle or NPCs immediately after reperfusion (as before), followed by animal sacrifice at 48 h. Note the increased counts of neutrophils, activated neutrophils, patrolling monocytes, CD4⁺ and CD8⁺ T cells, activated CD4⁺ T cells, B cells and NK cells in the blood of Western diet mice on NPCs. Data are medians (lines inside boxes)/means (crosses inside boxes) ± interquartile ranges with minimum/maximum values as whiskers. *P < 0.05/**P < 0.01/***P < 0.001 (n = 6 mice for normal diet/vehicle, n = 6 for normal diet/NPC, n = 5 for Western diet/vehicle, n = 7 for Western diet/NPC)