Fig. 6.

Enrichment analysis of GPCR–TME classifier. A, B GSEA of the high-/low-GPCR score groups A and the high-/low-TME score groups (B). C Dendrogram of clusters in which similar genes are classified into the same module. D Module–trait heatmap showing the blue module highly positively related to GPCR^low/TME^high subgroup and negatively related to GPCR^high/TME^low subgroup. E Enriched pathways of the blue module using Metascape. F fgsea showing the enriched pathways among the three GPCR–TME subgroups. G Analysis of anticancer immune status of the three GPCR–TME subgroups using TIP. GSEA Gene set enrichment analysis; GPCR: G protein-coupled receptor; TME: tumor microenvironment; TIP tracking tumor immunophenotype