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. 2023 Sep 15;27:86. doi: 10.1186/s40824-023-00422-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 9 — Stratified-structural hydrogel scaffold integrated with Mg ions-loaded BP nanosheets with good angiogenesis, osteogenesis and upregulation of nerve-related protein expression for promoting neuro-vascularized bone regeneration. a Schematic illustration of the bilayer hydrogel scaffold consisting of the upper (GelMA-BP@Mg) hydrogel and the bottom layer (GelMA-PEG/β-TCP) hydrogel. b Characterization of the bilayer hydrogel scaffolds. c In vitro angiogenesis evaluation of HUVECs on different hydrogel scaffolds. d Cell viability of HUVECs cultured on different hydrogels. e In vivo bone regeneration of rat calvarial defects treated with different hydrogel scaffolds. Images reproduced from [40], © 2022 Elsevier Ltd