Table 2.
Cell viability % of MCF-10 A cells upon treatment with 50 µM of compounds 7a-x for 96 h and IC50 of compounds 7a-x & Doxorubicin in A-549, MCF-7, Panc-1 and HT-29 after 48 h incubation
Compound | Cell viability % in MCF-10 A (50 µM) |
IC50 ± SEM (µM) | |||
---|---|---|---|---|---|
A-549 | MCF-7 | Panc-1 | HT-29 | ||
7a | 91 | 9.90 ± 1.10 | 9.20 ± 1.10 | 10.40 ± 1.30 | 11.15 ± 1.40 |
7b | 88 | 8.20 ± 0.90 | 7.90 ± 0.80 | 8.40 ± 1.00 | 9.10 ± 1.10 |
7c | 87 | 4.70 ± 0.50 | 4.15 ± 0.50 | 5.20 ± 0.40 | 5.50 ± 0.50 |
7d | 89 | 9.70 ± 1.10 | 8.90 ± 1.10 | 10.30 ± 1.30 | 11.10 ± 1.40 |
7e | 87 | 1.60 ± 0.30 | 1.25 ± 0.08 | 1.70 ± 0.30 | 1.95 ± 0.30 |
7f | 87 | 2.15 ± 0.50 | 2.05 ± 0.50 | 2.40 ± 0.60 | 2.70 ± 0.50 |
7g | 91 | 1.80 ± 0.60 | 1.45 ± 0.30 | 1.90 ± 0.50 | 2.10 ± 0.60 |
h | 87 | 1.95 ± 0.60 | 1.75 ± 0.40 | 2.05 ± 0.50 | 2.25 ± 0.60 |
7i | 84 | 9.70 ± 1.10 | 9.20 ± 1.00 | 10.15 ± 1.20 | 10.20 ± 1.30 |
7j | 89 | 9.95 ± 1.10 | 9.40 ± 1.20 | 10.30 ± 1.20 | 10.70 ± 1.10 |
7k | 91 | 1.20 ± 0.20 | 0.95 ± 0.08 | 1.30 ± 0.20 | 1.40 ± 0.20 |
7l | 89 | 1.45 ± 0.30 | 1.10 ± 0.10 | 1.50 ± 0.30 | 1.65 ± 0.30 |
7m | 94 | 1.40 ± 0.50 | 1.20 ± 0.08 | 1.50 ± 0.20 | 1.85 ± 0.40 |
7n | 92 | 1.90 ± 0.60 | 1.65 ± 0.30 | 2.05 ± 0.50 | 2.20 ± 0.60 |
7o | 89 | 7.60 ± 0.30 | 7.10 ± 0.60 | 8.20 ± 1.20 | 8.60 ± 0.40 |
7p | 87 | 2.50 ± 0.50 | 2.10 ± 0.20 | 3.10 ± 0.40 | 3.30 ± 0.40 |
7q | 94 | 3.40 ± 0.40 | 3.02 ± 0.30 | 3.80 ± 0.50 | 3.70 ± 0.50 |
7r | 91 | 3.60 ± 0.50 | 3.10 ± 0.50 | 3.90 ± 0.50 | 4.20 ± 0.50 |
7s | 87 | 3.80 ± 0.60 | 3.15 ± 0.50 | 4.30 ± 0.60 | 4.55 ± 0.60 |
7t | 88 | 10.60 ± 1.10 | 10.10 ± 1.00 | 10.90 ± 1.20 | 10.80 ± 1.20 |
7u | 90 | 2.25 ± 0.50 | 2.10 ± 0.08 | 2.40 ± 0.20 | 2.70 ± 0.50 |
7v | 87 | 2.45 ± 0.50 | 2.20 ± 0.08 | 2.60 ± 0.20 | 2.90 ± 0.50 |
7w | 91 | 10.90 ± 1.10 | 10.20 ± 1.20 | 11.15 ± 1.20 | 11.20 ± 1.30 |
7x | 85 | 11.50 ± 1.20 | 10.800 ± 1.10 | 11.80 ± 1.20 | 12.50 ± 1.50 |
Doxorubicin | - | 1.21 ± 0.10 | 0.90 ± 0.10 | 1.41 ± 0.10 | 1.01 ± 0.10 |