Table 4.
Effects of compound 7k, 7l, and 7m on caspases activity and amount of Cytochrome C in MCF-7 breast cancer cells
| Compound | Caspase-3 | Caspase-8 | Caspase-9 | Cytochrome C | ||||
|---|---|---|---|---|---|---|---|---|
| Conc (pg/mL) |
Fold change | Conc (ng/mL) | Fold change | Conc (ng/mL) | Fold change | Conc (ng/mL) | Fold change | |
| 7k | 501.600 ± 4.00 | 7.60 | 1.680 | 9.90 | 15.900 | 17.00 | 0.660 | 14.00 |
| 7l | 492.500 ± 4.00 | 7.50 | 1.570 | 9.30 | 15.100 | 16.00 | 0.595 | 13.00 |
| 7m | 473.600 ± 3.50 | 7.20 | 1.350 | 7.90 | 13.900 | 15.00 | 0.515 | 11.00 |
| Doxorubicin | 503.200 ± 4.20 | 7.65 | 1.750 | 10.00 | 16.200 | 17.40 | 0.604 | 13.10 |
| Control | 65.600 | 1.00 | 0.170 | 1.00 | 0.930 | 1.00 | 0.046 | 1.00 |