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. 2023 Sep 15;21:626. doi: 10.1186/s12967-023-04450-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Expression levels of selected miRNA and protein targets in cancer cell upon pemigatinib treatment. A Left: histograms show the expression of miR-186 and miR-195 and right: Western blots of CDK6, target of miR-195, and c-Myc, target of miR-186 and miR-195 in H1581 cells treated with Pem for 48 h. B Left: histogram showing the expression of miR-133b and right: Western blots of MET, a target of miR-133b, in KATO III cells treated with Pem for 48 h. C Left: histogram showing the expression of miR-139 and miR-186 and right: Western blots of EGFR, target of miR-139, and c-Myc, target of miR-186, in RT-112 cells treated with Pem for 48 h. Histograms represent the mean ± SEM of three experiments, and the dashed line indicates the control (NT). *p < 0.05; ***p ≤ 0.001; Student’s t-test