Table 1.
Patient characteristics prior to pregnancy in women who carried to delivery.
| Characteristic | ADTKD-MUC1 | ADTKD-UMOD | ADTKD-MUC1 and ADTKD-UMOD | Genetically unaffected | p-Value with person as cluster |
|---|---|---|---|---|---|
| Individuals (n) | 35 | 50 | 85 | 23 | |
| Pregnancies (n) | 74 | 90 | 164 | 50 | |
| Age during pregnancy (years, mean ± SD) | 28.27 ± 4.79 | 26.97 ± 4.79 | 27.56 ± 4.82 | 29.34 ± 4.09 | 0.032 |
| Total responses | 73 | 88 | 161 | 50 | |
| BMI (kg/m2 mean ± SD) | 22.05 ± 2.91 | 22.77 ± 4.45 | 22.48 ± 3.89 | 22.67 ± 3.83 | 0.85 |
| Total responses | 25 | 37 | 62 | 19 | |
| Diabetes (n (%)) | 0 | 3 (3%) | 3 (2%) | 0 | 0.0094 a |
| Gout (n (%)) | 0 | 5 (6%) | 5 (3%) | 0 | 0.0020 a |
| Hypertension (n (%)) | 3 (4%) | 9 (10%) | 12 (7%) | 0 | <0.0001 a |
| Anemia (n (%)) | 20 (27%) | 20 (22%) | 40 (24%) | 1 (2%) | 0.035 |
| In vitro fertilization used (n (%)) | 1 (1%) | 1 (1%) | 2 (1%) | 1 (2%) | 0.69 |
| Other disease (n (%)) | 4 (5%) | 2 (2%) | 6 (4%) | 1 (2%) | 0.87 |
| Urine protein present (n (%)) | 0 | 3 (3%) | 3 (2%) | 0 | 0.0095 a |
| Smoked (n (%)) | 7 (9%) | 15 (17%) | 22 (13%) | 1 (2%) | 0.10 |
| Drank > 1 drink/week (n (%)) | 23 (31%) | 15 (17%) | 38 (23%) | 20 (40%) | 0.16 |
| Used marijuana or cocaine (n (%)) | 2 (3%) | 2 (2%) | 4 (2%) | 0 | 0.0020 a |
| Did not drink, smoke, or use drugs (n (%)) | 46 (62%) | 62 (69%) | 108 (66%) | 29 (58%) | 0.46 |
| Took allopurinol during pregnancy (n) | 0 | 0 | 0 | 0 | |
| Took febuxostat during pregnancy (n) | 0 | 0 | 0 | 0 | |
| Took an angiotensin converting enzyme inhibitor during pregnancy (n (%)) | 1 (1%) | 2 (2%) | 3 (2%) | 0 | |
| Took an angiotensin receptor blocker during pregnancy (n) | 0 | 0 | 0 | 0 | |
| Responses to questions about family planning | |||||
| “I knew there was kidney disease in my family prior to pregnancy.” (n (%)) | 36 (49%) | 44 (49%) | 80 (49%) | 37 (74%) | 0.060 |
| “I knew I had inherited kidney disease prior to pregnancy.” (n (%)) | 5 (7%) | 22 (24%) | 27 (16%) | NA | |
| “I told my doctor I had inherited kidney disease.” (n (%)) | 3 (4%) | 18 (20%) | 21 (13%) | NA | |
| “I discussed family planning.” (n (%)) | 8 (11%) | 9 (10%) | 17 (10%) | 1 (2%) | 0.14 |
| “My doctor discouraged pregnancy.” (n (%)) | 0 | 2 (2%) | 2 (1%) | NA | |
| “My doctor recommended pregnancy termination.” (n (%)) | 0 | 3 (3%) | 3 (2%) | NA | |
a
Due to null values, a permutation test was performed with 100,000 resamples to determine statistical significance.