Table 2.
Maternal complications in pregnancies carried to delivery in 35 women with ADTKD-MUC1, 50 women with ADTKD-UMOD and 23 unaffected family members.
| Characteristic | ADTKD-MUC1 | ADTKD-UMOD | ADTKD-MUC1 and ADTKD-UMOD | Unaffected | CKD Stage a | |||
|---|---|---|---|---|---|---|---|---|
| Stage 1 | Stage 2 | Stage 3 | Stage 4 | |||||
| Pregnancies (n) | 74 | 90 | 164 | 50 | 32 (20%) | 58 (37%) | 54 (34%) | 15 (9%) |
| Twin or greater (n (%)) | 2 (3%) | 0 | 2 (1%) | 0 | 0 | 1 (2%) | 1 (2%) | 0 |
| Prior hypertension | 3 (4%) | 9 (10%) | 12 (7%) | 0 | 1 (3%) | 3 (5%) | 6 (11%) | 2 (13%) |
| Diagnosed with new onset high blood pressure during pregnancy (n/pregnancies without prior hypertension (%)) b | 6/71 (8%) | 17/81 (21%) | 23/152 (15%) | 6/50 (12%) | 4/31 (13%) | 6/55 (11%) | 11/48 (23%) | 2/13 (17%) |
| High blood pressure during pregnancy (n (%)) | 9 (12%) | 26 (29%) | 35 (21%) | 6 (12%) | 5 (16%) | 9 (16%) | 17 (31%) | 4 (27%) |
| Hospitalized for high blood pressure (n (%)) | 3 (4%) | 9 (10%) | 12 (7%) | 1 (2%) | 1 (3%) | 3 (5%) | 8 (15%) | 0 |
| Diabetes (n (%)) | 1 (1%) | 1 (1%) | 2 (1%) | 4 (8%) | 1 (3%) | 1 (2%) | 0 | 0 |
| Gout (n) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Proteinuria (n (%)) | 4 (5%) | 5 (6%) | 9 (5%) | 1 (2%) | 1 (3%) | 2 (3%) | 6 (11%) | 0 |
| Seizures (n (%)) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Anemia (n (%)) | 10 (14%) | 9 (10%) | 19 (12%) | 1 (2%) | 6 (19%) | 3 (5%) | 5 (9%) | 5 (33%) |
| New anemia (n (%)) | 8 (11%) | 4 (4%) | 12 (7%) | 1 (2%) | 5 (20%) | 0 | 3 (8%) | 4 (31%) |
| Receive erythropoietin or darbopoietin or similar agent to increase hemoglobin (n (%)) | 3 (4%) | 0 | 3 (2%) | 0 | 0 | 0 | 1 (2%) | 2 (13%)* |
| Swelling in feet or hands (n (%)) | 18 (24%) | 27 (30%) | 45 (27%) | 12 (24%) | 2 (6%) | 20 (34%) ** | 16 (30%) * | 7 (47%) ** |
| Maintained follow up during pregnancy (n (%)) | 47 (64%) | 70 (78%) | 117 (71%) | 36 (72%) | 20 (63%) | 44 (76%) | 37 (69%) | 14 (93%) |
| Other health complications (n (%)) | 11 (15%) | 9 (10%) | 20 (12%) | 5 (10%) | 4 (13%) | 8 (14%) | 4 (7%) | 4 (27%) |
| Pregnancies (n) | 74 | 90 | 164 | 32 | 55 | 42 | 7 | |
| Worsening kidney function (n (%)) | 7 (9%) | 10 (11%) | 17 (10%) | NA | 0 | 4 (7%)* | 9 (17%)** | 4 (27%)** |
| Dialysis (n (%)) | 0 | 1 (1%) | 1 (1%) | NA | 0 | 1 (2%) | 0 | 0 |
a
Five pregnancies were not able to be categorized for CKD stage.
b
The denominator for this row is the number of patients who did not have high blood pressure prior to pregnancy.
*Significantly different than Stage 1 at p < 0.05, **significantly different than Stage 1 at p < 0.01.