Table 3.
Comparison of pregnancy studies in CKD.
| Wu et al. 3 | Chapman et al. 5 | Piccoli et al. 4 | Wiles | ADTKD Cohort Study | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Population | ADPKD | ADPKD | CKD Stage 2 | CKD Stage 3 | 3a | 3b | Unaffected | Estimated CKD Stage 1 | Estimated CKD Stage 2 | Estimated CKD Stage 3 | Estimated CKD Stage 4 |
| Mothers (n) | 54 | 235 | 23 | 35 women with ADTKD-MUC1 and 50 with ADTKD-UMOD | |||||||
| Pregnancies (n) | 92 | 485 | 87 | 37 | 79 | 38 | 50 | 32 | 58 | 54 | 15 |
| BMI (kg/m2 mean ± SD) | 26.4 | 24.9 | 23.0 ± 4.5 | 22.21 ± 3.30 | 23.58 ± 5.35 | 21.59 ± 2.18 | 22.96 ± 4.99 | ||||
| Mean age (years; mean ± SD) | 29 ± 6.2 | 33.8 ± 4.5 | 33.5 ± 4.1 | 33.2 | 33.1 | 29.3 ± 4.1 | 27.41 ± 5.02 | 28.69 ± 4.79 | 26.40 ± 4.78 | 27.14 ± 4.52 | |
| Hypertension prior to pregnancy (n or % as given in paper) | ≥20% | 16% | 41% | 54% | 71% | 87% | 0 | 1 (3%) | 3 (5%) | 6 (11%) | 2 (13%) |
| Hypertension during pregnancy (baseline HTN + new onset HTN) | ≥32% | 32% | 52% | 76% | ≥71% | ≥87% | 6 (12%) | 5 (16%) | 9 (16%) | 17 (31%) | 4 (27%) |
| New onset hypertension (n) | 12% | 16% | 18% | 47% | 6 (12%) | 4 (13%) | 6 (11%) | 11 (23%) | 2 (17%) | ||
| Edema (n) | 11% | 25% | 12 (24%) | 2 (6%) | 20 (34%) | 16 (30%) | 7 (47%) | ||||
| Preeclampsia (n) | 9% | 11% | |||||||||
| Premature delivery (<37 weeks) (n or % as given in paper) | 11% | 9% | 51% | 78% | 41% | 62% | 0 | 1 (3%) | 2 (3%) | 12 (21%) | 1 (7%) |
| Cesarean section (n or % as given in paper) | 14% | 7% | 70% | 78% | 51% | 65% | 19 (38%) | 6 (19%) | 8 (14%) | 13 (24%) | 4 (27%) |
| NICU stay | 28 | 44 | 24% | 41% | 3 (6%) | 2 (6%) | 5 (9%) | 11 (20%) | 1 (7%) | ||
| Birth weight (g) (mean ± SD) | 3289 ± 746 | 2484 ± 707 | 2226 ± 582 | 2750 | 2490 | 3760 ± 581 | 3352 ± 621 | 3515 ± 540 | 2993 ± 721 | 3293 ± 744 | |
| Decline in eGFR (ml/min/1.73 m2/year) | 2.9 | 4.6 | |||||||||