HaeIII profiles of pbp2b amplicons from penicillin-susceptible (MICs, ≤0.03 μg/ml) (s1 and s2) and penicillin-resistant (MICs, 0.06 to 4.0 μg/ml) (r1 to r9) clinical blood isolates of pneumococci. Lane 1, r2; lane 2, r8; lane 3, r5; lane 4, r4; lane 5, r3; lane 6, r1; lane 7, r9; lane 8, r7; lane 9, r6; lane 10, s2; lane 11, s1, lane 12, Gibco-BRL kilobase ladder.