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Comparison of the pbp2b sequence of low-level penicillin-resistant (MIC, 0.25) pneumococcal isolate 5 with that of penicillin-susceptible strain R6. Nucleotide numbering was taken from reference 4. Codons encoding amino acid substitutions and the indicated RsaI site are in bold-faced type. Nonconservative codon substitutions and a perfect match to the R2 primer sequence used by du Plessis et al. in detecting penicillin resistance (5a) are underlined.
