Table 3.
The AUC and 95% CI of the 8 Candidate Biomarkers
| Metabolites | LTBI vs HC | ATB vs LTBI | ATB vs HC | |||
|---|---|---|---|---|---|---|
| AUC | 95% CI | AUC | 95% CI | AUC | 95% CI | |
| Deoxycholic Acid | 0.714 | 0.5849–0.8440 | 0.741 | 0.6160–0.8668 | 0.912 | 0.8425–0.9818 |
| 13,14-dihydro-15-keto-tetranor Prostaglandin D2 | 0.727 | 0.5965–0.8569 | 0.731 | 0.5995–0.8631 | 0.920 | 0.8458–0.9946 |
| LysoPC 12:1 | 0.661 | 0.5211–0.8012 | 0.847 | 0.7535–0.9415 | 0.904 | 0.8316–0.9765 |
| (5-L-Glutamyl)-L-Amino Acid | 0.750 | 0.6244–0.8756 | 0.741 | 0.6141–0.8687 | 0.893 | 0.8145–0.9713 |
| Hypoxanthine | 0.830 | 0.7252–0.9348 | 0.708 | 0.5747–0.8414 | 0.929 | 0.8634–0.9952 |
| Xanthosine | 0.821 | 0.7141–0.9282 | 0.691 | 0.5585–0.8253 | 0.909 | 0.8381–0.9801 |
| N8-Acetylspermidine | 0.723 | 0.5921–0.8546 | 0.783 | 0.6639–0.9038 | 0.909 | 0.8267–0.9915 |
| 3,4-Dimethylbenzoic acid | 0.740 | 0.6126–0.8674 | 0.773 | 0.6526–0.8929 | 0.889 | 0.8097–0.9681 |
Abbreviations: HC, healthy controls; LTBI, latent tuberculosis infection; ATB, active tuberculosis; AUC, area under the curve; CI, confidence interval.