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. 2023 Sep 17;17(2):84–92. doi: 10.2478/abm-2023-0048

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© 2023 Nhung Phuong Vu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution 4.0 International License.

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Figure 1. — Graphical illustration of CYP450 CNVs identified in current study. (A) Reference gen locus of CYP1B1 (up) and CYP1B1Dup allele (down). CYP1B1 located on chromosome 2 and represented by yellow boxes. (B) Reference gen locus on chromosome 19 of CYP2A6 (orange box) and pseudogene CYP2A7 (grey box) (up) and CYP2A6Del allele (down), downstream of exon 9 of CYP2A6 is denoted by the black boxes. Primers position and strategy used for CYP2A6 del allele detection are also shown. (C) Reference gene cluster on chromosome 10 including CYP2C9 (blue box), CYP2C8 (green box) (up), and CYP2C9 Del allele (down). (D) Reference gen locus of CYP2E1 (pink box) on chromosome 10 (up), CYP2E1Del allele (middle), and CYP2E1Dup allele with 2 copies of the gene (down). CNVs, copy number variations.