Table 1.
Baseline characteristics of participants receiving nirmatrelvir-ritonavir or azvudine before and after propensity-score matching
| Basline characteristics | Before matching patients | After 1:1 propensity-score matching patients | ||||
|---|---|---|---|---|---|---|
| Nirmatrelvir-ritonavir (n = 272) | Azvudine (n = 156) | P valuea | Nirmatrelvir-ritonavir (n = 143) | Azvudine (n = 143) | P valuea | |
| Age, mean ± SD, yr | 77.68 ± 13.42 | 76.67 ± 11.83 | 0.436 | 76.83 ± 13.47 | 76.45 ± 12.10 | 0.803 |
| Sex, n (%) | 0.150 | 0.716 | ||||
| Male | 176 (64.71) | 90 (57.69) | 89 (62.24) | 86 (60.14) | ||
| Female | 96 (35.29) | 66 (42.31) | 54 (37.76) | 57 (39.86) | ||
| BMI, mean ± SDb,c | 22.99 ± 3.32 | 22.81 ± 2.99 | 0.576 | 22.82 ± 3.15 | 22.90 ± 3.05 | 0.829 |
| Severity of COVID-19 before antivirals, n (%) | 0.927 | 0.632 | ||||
| Mild to moderate | 231 (84.93) | 133 (85.26) | 118 (82.52) | 121 (84.62) | ||
| Severe | 41 (15.07) | 23 (14.74) | 25 (17.48) | 22 (15.38) | ||
| Smoking, n (%) | 18 (6.62) | 13 (8.33) | 0.510 | 11 (7.69) | 12 (8.39) | 0.828 |
| Drinking, n (%) | 12 (4.41) | 11 (7.05) | 0.244 | 6 (4.20) | 10 (6.99) | 0.303 |
| Diabetes, n (%) | 62 (22.79) | 46 (29.49) | 0.125 | 42 (29.37) | 39 (27.27) | 0.694 |
| Cardiovascular disease, n (%) | 90 (33.09) | 56 (35.90) | 0.555 | 51 (35.66) | 49 (34.27) | 0.804 |
| Chronic lung disease, n (%) | 57 (20.96) | 15 (9.62) | 0.003 | 14 (9.79) | 15 (10.49) | 0.845 |
| Tumor and immunosuppression, n (%) | 84 (30.88) | 24 (15.38) | < 0.001 | 27 (18.88) | 24 (16.78) | 0.643 |
| LTM, median (IQR), × 109/Lb | 0.80 (0.50, 1.10) | 1.00 (0.70, 1.30) | < 0.001 | 0.80 (0.60, 1.20) | 1.00 (0.70, 1.30) | 0.033 |
| D-dimer, median (IQR), mg/Lb | 0.97 (0.56, 2.07) | 0.88 (0.50, 1.56) | 0.053 | 0.88 (0.50, 1.84) | 0.87 (0.48, 1.56) | 0.716 |
| CRP, median (IQR), mg/Lb | 40.35 (14.18, 80.00) | 20.90 (5.49, 58.58) | < 0.001 | 27.90 (10.62, 65.80) | 24.10 (5.41, 64.90) | 0.261 |
Abbreviations: IQR interquartile range, LTM lymphocyte count, CRP C-reactive protein, BMI body mass index
aP value was based on Student’s t-test, the Mann–Whitney U test, χ2 tests, or Fisher’s exact test, as appropriate
bMissing data: 34 for BMI, 2 for LTM, 2 for D-dimer, and 4 for CRP
cBMI was calculated as weight in kilograms divided by height in meters squared