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. 2023 Sep 16;7:92. doi: 10.1038/s41698-023-00448-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Hierarchical clustering heat map of all DEGs with log2FC (fold change) values > 2 and p < 0.05. Rows represent brain tissue samples acquired from the FUS-sonicated (FUS) or nonsonicated (CON) tumor regions from different patients, and columns represent individual DEGs. b Summary of the total number of upregulated and downregulated DEGs. c Upregulated (red) and downregulated (blue) DEGs with GO functional analysis for enriched biological processes, cellular components, and molecular functions. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001. d Upregulated and downregulated genes involved in GO terms related to cell physical structure. e Upregulated and downregulated genes involved in GO terms related to inflammatory or immune-related response.