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. 2023 Sep 16;13:15377. doi: 10.1038/s41598-023-41846-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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En face LIV, OCDS $_{l}$ , and fluorescence images of an HT-29 spheroid treated with SN-38. The LIV and OCDS $_{l}$ patterns are very different to those for MCF-7 when treated with PTX (Fig. 1). Specifically, the LIV images of the TD-1 spheroids show high LIV (green) at the center surrounded by low LIV (red). After longer treatment times, the LIV images show a granular appearance. The OCDS $_{l}$ images show concentric domain structures. In addition, the OCDS $_{l}$ and fluorescence images are found to be highly correlated. Magnified images of HT-29 spheroids with sever volume reduction and shape corruption. High levels of pattern correlation between the OCDS $_{l}$ and fluorescence patterns are observed. The scale bars represent 200 μm.