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. 2023 Sep 16;13:15377. doi: 10.1038/s41598-023-41846-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Detailed analysis of apparent pattern differences between the control MCF-7 (left) and HT-29 (right) spheroids. (a), (g) Cross-sections of the OCT intensity, LIV, and OCDS $_{l}$ . (b), (h) Time course of the OCT intensity in the core areas of the spheroids (as indicated by the yellow boxes). MCF-7 shows very low fluctuations, while HT-29 shows high levels of fluctuation. (c), (i) Auto-correlation curves for both spheroids, showing rapid decay as the auto-correlation became very low at the first sampling point of the delay time (204.8 ms). (d), (j) The autocorrelation curves with high temporal density show details of the autocorrelation decay at short correlation delay time. (e), (k) OCDS $_{e}$ cross-sections of the same spheroids, showing the fast decay (green) at the center parts of the spheroid. These OCDS $_{e}$ images were computed from a cross-sectional frame sequence of 350 frames acquired at a single location. (f), (l) Bright-field microscopy images of the spheroids, which show the necrotic cores as dark central region.